Roles of Pseudomonas aeruginosa-derived proteases as a virulence factor
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چکیده
منابع مشابه
Antibiotic resistance profiles of Pseudomonas aeruginosa isolates containing virulence genes
Background: A most common opportunistic pathogen, Pseudomonas aeruginosa is present in both humans and animals and responsible for various nosocomial infections and healthcare settings related infections. Different virulence genes like; oprL (membrane lipoprotein L) and toxA (exotoxin A i.e. ETA) in P. aeruginosa, assist in its pathogenicity, toxicity and contribute to high antibiotic resistanc...
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Pathogenic bacteria need to interact with their host to establish an infection and to maintain it successfully afterwards. This requires to “understand” signals of the immune-system and to “respond” appropriately when the host tries to defend himself. Part of the response of successful pathogens is secretion of so called virulence factors which manipulate or even destroy defense lines of the ho...
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The roles of the Pseudomonas aeruginosa proteases LasB (elastase) and LasA and the transcriptional activator LasR, which regulates the expression of these proteases, were evaluated in a murine model of P. aeruginosa corneal infection. In scarified corneas, P. aeruginosa PAO-A1 (LasA negative) or PAO-B1A1 (LasB and LasA negative) at a dose of 10(8) CFU per eye caused very mild or no disease foll...
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Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen with high antibiotic resistance. Its lectin LecB was identified as a virulence factor and is relevant in bacterial adhesion and biofilm formation. Inhibition of LecB with carbohydrate-based ligands results in a decrease in toxicity and biofilm formation. We recently discovered two classes of potent drug-like glycomimetic inhibito...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 2013
ISSN: 0021-4930,1882-4110
DOI: 10.3412/jsb.68.313